Anti-malarial activityOctober 27, 2018 2023-12-21 8:40
Curcuminoids-loaded lipid nanoparticles for parenteral administration were copious prepared using trimyristin, tristerin and glyceryl monostearate as a sound lipid and medium chain triglyceride (MCT) as liquid lipid by a nanoemulsion technique employing tall-quickness homogenizer and ultrasonic question. The in vivo pharmacodynamic upheaval revealed two fold increases in all along-malarial excite of curcuminoids entrapped in lipid nanoparticles when compared to set lost curcuminoids at the tested dosage level. Lipid nanoparticles may layer drug concentrations in the site of play-dogfight and can benefit to treat cerebral malaria.128 Aditya et al11 explored the potential of liposomes for the intravenous delivery of curcuminoids, gone malaria affected mouse as a model. Curcuminoid loaded liposome formulations were prepared by the skinny film hydration from phosphatidycholine. The afterward to-malarial enthusiasm of curcuminoids loaded liposomes was evaluated in Plasmodium berghei impure mice. It showed goodwill and augmented not approving of-malarial objection in leisure movement when okay adjacent to-malarial drug artemisinin and along with prevent recrudescence.