Category: Cancer
Breast cancer Curcumin as Potent Chemosensitizer
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Curcumin could assist as a chemosensitizer for new anticancer agents in treating human breast cancer cells, especially multi-drug-resistant (MDR) breast cancer cells. Limtrakul et al. investigated the effects of tetrahydrocurcumin almost three ATP-binding record (ABC) drug transporters, including P-glycoprotein (ABCB1/P-gp),…
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Cancer Reactive Oxidative Stress
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Reactive oxidative put inflection on (ROS) expresses double-sided effects a propos carcinogenesis. On the one hand, ROS triggers cancer by DNA mutations. On the growth hand, ROS has in addition to been reported in some literature to kill tumor cells….
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Breast cancer Immune and Metastasis Factors
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Curcumin suppresses the accretion of breast cancer partially by mediating the immune system. Recent research has indicated that curcumin could prevent the loss of T cells and inhibit immune suppressive cytokines, including transforming grow factor beta (TGF-) and interleukin 10…
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Breast cancer Modulation of MicroRNA
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Curcumin suppresses breast cancer oncogenesis partially due to modulation of microRNA (miR), DNA, histone, and mitochrondria. The drying of miR-15a, miR-16, and miR-34a was upregulated in curcumin-treated cell models, and that of Bcl-2 and Bmi-1 was downregulated. Besides, recent evidence…
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Cancer Cell Phase Arrest
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Curcumin could furthermore do its stuff human breast cancer cells through inducing cell cycle arrest at the G2M phase and late S phase in MCF-7 cells. Curcumin led to an obvious late buildup of the G2M phase piece. Furthermore, Ke…
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Breast cancer apoptosis
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Curcumin is reported to induce breast cancer apoptosis by adaptable the exposure to atmosphere of apoptosis joined genes. Lv et al. applied microarray hybridization of lone-tech apoptotic arrays gone labeled first-strand probes of firm RNA to analyze and describe the…
Read MoreCancer Proliferation
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In breast cancer cells, the survival signaling molecules, such as NF-B, produce a consequences a pivotal role in cell proliferation44 (Fig. 2). Liu et al. reported that curcumin was sprightly to inhibit NF-B expression45 and toggled many downstream signaling pathways,…
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Techniques for Extraction and Purification of Curcumin
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Curcumin longa L. (turmeric) contains 2%9% curcuminoids, including curcumin, demethoxycurcumin and bisdemethoxycurcumin, and cyclic curcumin. Among them, curcumin is considered the most important biomedical molecule. Since 1815, after that the first report of descent and purification of curcumin was published,…
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Curcumin in Treating Breast Cancer: A Review Introduction
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Breast cancer is the most commonly diagnosed malignant tumor and the second leading cause of cancer mortality in the middle of women in the United States.1 About 70% of breast cancers are classified as estrogen receptor (ER) be down and…
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