Kim et al127 investigated the potential in contradiction of-diabetic mechanisms of CUR, curcumin C3 secret and tetra hydrocurcuminoids (THC). They with demonstrated that curcuminoids effectively suppressed dexamethasone-induced phosphoenol pyruvate carboxy kinase (PEPCK) and glucose6-phosphatase (G6Pase) in H4IIE rat hepatoma and Hep3B human hepatoma cells. In collaborator curcuminoids increased the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream ambition acetyl-CoA carboxylase (ACC) in H4IIE and Hep3B cells once 400 period considering CUR to 1,00,000 period together together in addition to THC the potency of metformin. AMPK mediated suppression of hepatic gluconeogenesis can be a potential mechanism mediating glucose-lowering effects of curcuminoids and can find the money for an additional recognition in the giving out of diabetes.