Three manganese complexes of CUR and related compounds, diacetylcurcumin (AcylCUR) and ethylenediamine derivatives (CURED) were synthesized and evaluated by in vitro for not well-disposed of-lipid peroxidatioin and superoxide dismutase exchange. The complexes potentiated neuroprotective effects adjoining learning and memory impairment in transient cerebral ischemic mice and as regards H2O2- induced cell irregular in NG108-15 cells. The prepared manganese complexes of CURCURx and AcylCURCURx showed bigger neuroprotective effects in both 2VO-water maze task and cell culture models. The protective effect of Acyl-CURCURx was simply demonstrated by MPTP-induced dopaminergic neurotoxicity in mice and as well as suggested a role for super oxide dismutase mimics in the sponsorship of neutrodegeneration mediated by chemicals and drugs. AcylCURCURx and CURCURx can be the most promising neuroprotective agent for vascular dementia.93 Ferrari et al94 investigated the metal complexing operate a share of substituted curcuminoids of auxiliary chelating molecules using gallium (III) and copper (II), following biological properties comparable considering curcumin back bigger stability as new potential Alzheimer’s disease therapeutic agents. The K2T derivatives originate from the insertion of a eCH2COOC(CH3)3 intervention around the central atom of the diketonic moiety of curcumin. In aqueous conclusive the prevalent form is the diketo one, but the adding together of metal ion (Ga3 and Cu2) causes the dissociation of the enolic proton creating chelate complexes and varying the tautomeric equilibrium towards the keto-enol form. The bond dissociation moving picture (BDE) values of the ligands suggested that skirmish delocalization plays an important role in determining the scavenging triumph. Ga (III) can be utterly promising as superoxidescavengers to use in super oxide dismutase mimics.