Curcumin based metallointercalators subsequent to amino acid such as cysteine has been synthesized by Chandrasekar et al.99 The ligand is coordinated via ketimine, carbonyl and enolic oxygen of CUR analog and the complexes have the composition of metal-ligand type. The prepared complexes are hermetic intercalators and the potential nucleases as compared to CUR based forgive ligand and the complexes are moreover exhibited greater than before to-do neighboring to bacteria and fungi than the ligand.