A vanadyl curcumin puzzling was prepared by Thompson et al98 for touching-rheumatoid arthritis. Vanadyl curcumin was more functional in inhibition of serene muscle cell augmentation, synoviocyte proliferation and mouse lymphoma cell mount taking place than CUR alone. It was an efficient inhibitor of synoviocyte proliferation and suggested striking potential as a particular non-toxic treatment for rheumatoid arthritis. The vanadyl curcumin puzzling was ineffective as an insulin mimetic agent proved by an acute and chronic screening test moreover, it moreover proved to be exceptionally non-toxic, subsequent to no evidence of negative symptomatology during a month-long treatment era.