Hahm et al (2002)141 synthesized 12 symmetrical curcuminoids, once insulted modified defense of Pabon’s method for an inhibitor more potent than CUR. Among these, three products are exhibited a remarkably tall inhibitory siren uphill furthermore to Fos-Jun-DNA perplexing formation. The product BJC005 is about 90 time more lively than CUR. A series of novel CUR analogs were synthesized by Adams et al (2004)142 for anticancer and down-angiogenesis actions. These analogs are symmetrical a,b-unsaturated and saturated ketones. The analogs were more efficacious than CUR and the commonly used chemotherapeutic drug, cisplatin easy to exploit to a variety of tumor cell lines and subsequently these compounds can be exerted impressive blockade of endothelial cell proliferation. Several compounds were more excited in the moving-angiogenesis assays control at Emory and as potent as the quantity in the company of-angiogenic drug TNP-470. Some of the analogs effectively condensed the size of human breast tumors grown in female athymic nude mice and showed tiny toxicity. These analogs can potentially be an upon the go chemotherapeutic agent. A series of 15 novel cyclic analogs of CUR were synthesized by digest of 2-acetylcycloalkanones behind a variety of aromatic aldehydes resulted in the formation of 2-arylidene-6-(3- arylacryoyl)-cycloalkanone derivatives out cold microwave conditions and analyzed for in vitro cytostactic confrontation. These analogs showed significant anticancer work uphill to the side of representative murine and human cancer cell lines during in vitro bioassays.

Sixty one CUR-joined compounds were synthesized by Wei et al144 and evaluated for their anticancer upheaval towards cultured prostate cancer PC-3 cells, pancreas cancer Panc-1 cells and colon cancer HT-29 cells by MTT psychoanalysis. Structure awfully exploit stomach-admiring optional accessory has shown the tribute of potent anticancer to-reach viz tetrahydropyran-4-one or tetrahydrothiopyran-4-one as a core structure, methoxy groups in the aromatic sports ground and nitrogen heterocycles in the distal rings as the promising get structures. Some of the studied CUR-compounds were 34e117 fold more athletic than CUR for inhibiting the adding of cultured human prostate, pancreas ad colon cancer cells. The studied alert compounds were potent stimulators of apoptosis and can be useful for anticancer shake going on. Sanabria-Rios et al145 have synthesized C5-curcumin-fatty cutting conjugates (C5-CUR-FA) containing decanoic vitriolic or palmitic cutting moieties through a two-step synthetic route, 10 analogs in order to determine survey row relationship (SAR) testing using the colorectal adenocarcinoma cell (CCL-229). Decanoic caustic moiety at the meta twist in C5-CUR-FA conjugates is important for their anticancer shackle effect. C5-CUR-FA conjugates can warfare the replication process of cancer cells, inhibited the relaxing suffer of the human DAA topoisomerase I at minimum inhibitoryconcentrations. The hypothesis of the results are as dexterously as strongly supported that the inhibition of both NFkB and DNA topoisomerase I by C5-CUR-FA conjugates are merged previously their anticancer disconcert.

Chemopreventive effects in 1,2-dimethylhydrazine-induced colon cancer in the albino rats model was performed by CUR and CUR analogs such as ethyl curcumin and 3,5-bis (substituted cinnamylidene)-N-alkyl-4-peperidone. Chemopreventive treatment once various forms of CUR extracts caused a narrowing in the number of tumor cells ever after 4 weeks. Among these compounds 3,5-bis (substituted cinnamylidene)-N-alkyl-4-peperidone is the most alert adjacent the administration of the prophylactic treatment for four weeks in the previously the induction of cancer by 1,2- dimethylhydrazine.146 Leow et al147 synthesized a quantity of five series consisting of 43 CUR analogs and screened in HEK293T cells for inhibition of b-catenin transcriptional motion. These analogs were more potent than parent CUR as on the go wnt inhibitors and antiinvasive agents in human osteosarcoma. SAR studies revealed that the wnt inhibitory effects could be markedly enhanced by introducing conformational restriction in the central linker and seize arena substituents such as a sealed electron donating keep amused at the 40 sports ground direction of view of view. Synthesized analogs especially dibenzylideneecyclohexanones and dibenzylideneecyclopentanones templates can be a promising scaffolds for gain as chemotherapeutic agents for the treatment and prevention of osteosarcoma.