Bisacurone has been found to exhibit antioxidant, linked in the middle of-inflammatory, and antimetastatic tricks [109]. Bisacurone downregulated TNF-induced vascular cell adhesion molecule-1 (VCAM-1) exposure to atmosphere in human umbilical vein endothelial cells [109]. In adviser, bisacurone inhibited ROS generation and NF-B activation induced by TNF. Bisacurone moreover inhibited phosphorylation of Akt and PKC and decreased adhesion of human monocytes and oral cancer cells to human umbilical vein endothelial cells stimulated by TNF. All these results counsel that bisacurone may exhibit anticancer ruckus through the downmodulation of gain-inflammatory pathways.