All 3 types of Down syndrome are genetic conditions (relating to the genes), but and no-one else 1% of all cases of Down syndrome have a hereditary component (passed from parent to child through the genes). Heredity is not a factor in trisomy 21 (nondisjunction) and mosaicism. However, in one-third of cases of Down syndrome resulting from translocation there is a hereditary component accounting for not quite 1% of all cases of Down syndrome.

The age of the mother does not seem to be associated to the risk of translocation. Most cases are flashing unintentional activities. However, in roughly one-third of cases, one parent is a carrier of a translocated chromosome.

What Is the Likelihood of Having a Second Child when Down Syndrome?

Once a girl has innocent birth to a baby as soon as trisomy 21 (nondisjunction) or translocation, it is estimated that her chances of having choice baby taking into account trisomy 21 is 1 in 100 happening until age 40.

The risk of recurrence of translocation is practically 3% if the father is the carrier and 10-15% if the mother is the carrier. Genetic counseling can determine the parentage of translocation.

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