CUR has extensive cardioprotective effects contiguously diabetic cardiovascular complications, cardiac hypertrophy and myocardial infarction. Hong et al67 assessed and explored the molecular mechanism of the cardioprotective effects of CUR by a rat model of coronary artery ligation. The genechip results suggested that gene discussion in the stick zone of infracted left ventricle of rats is a dimensional process after myocardial infarction. After treatment subsequent to CUR some amelioration in cardiac produce a result, infarct sixe and serum biochemical markers were noted. Cardioprotective effects CUR are similar subsequently cytokine-cytokine receptor contact, ECM-receptor relationships, focal adhesions and colorectal cancer. The idiopathic pulmonary arterial hypertension is a profound sickness that mainly affects pulmonary arterial circulation. This undergoes a remodeling as well as than subsequent narrowing of flow in the small pulmonary arteries. Because of this broken an increased vascular resistance gradually develops and on summit of times it carries out in hears failure. CUR has been considered a potent antiinflammatory agent useful for inflammatory diseases. Long investigations of all along-inflammatory effects of CUR showed a role for inactivation of NF-jB mediated inflammation.