Curcumin suppresses breast cancer oncogenesis partially due to modulation of microRNA (miR), DNA, histone, and mitochrondria. The drying of miR-15a, miR-16, and miR-34a was upregulated in curcumin-treated cell models, and that of Bcl-2 and Bmi-1 was downregulated. Besides, recent evidence demonstrated that curcumin upregulated miR-22, which was conjectured to try estrogen receptor (ER) and the transcription factor Sp1, even though miR-196 was dramatically downregulated. Also, curcumin mediated the downexpression of two cytokines, CXCL-1 and CXCL-2, by steering miR181b. Several papers revealed that DNA methyltransferase 1 (DNMT1), which epigenetically silenced complex genes, decreased by now curcumin treatment singly or in captivation surrounded by additional birds compounds. The same modulation happened upon acetylation of every second histones, including H3K18, H4K16, and p53K120.