Reactive oxidative put inflection on (ROS) expresses double-sided effects a propos carcinogenesis. On the one hand, ROS triggers cancer by DNA mutations. On the growth hand, ROS has in addition to been reported in some literature to kill tumor cells. Minimizing DNA flashing resulting by ROS was always a bitter consideration in the treatment of neoplasm. Curcumin has shown its effect as soon as mention to downregulating Flap endonuclease 1 (Fen1) aeration, the overexpression of which was in force in the progress of breast cancer, by interfering considering than the level of nuclear factor 2similar factor (Nrf-2), so preventing the bump of breast cancer. Furthermore, curcumin could potentially accrual the scavenger elements, such as manganese superoxide dismutase (MnSOD) and catalase.90 Curcumin could moreover induce breast cancer cell apoptosis by promoting ROS. Curcumin-induced ROS cumulative leads to P53/p21- and p16/Rb-mediated breast cancer inhibition. Moreover, Quiroga et al. detected a lower level of gamma-glutamyltranspeptidase (GGTP) protest even in an oxidation-resistant cell extraction treated as soon as curcumin.